Acid Dissociation of Serotonin(5-Hydroxytryptamine) and 5-Hydroxytryptophan

Blood and urine 5-hydroxytryptophan and 5-hydroxytryptamine levels after administration of two 5-hydroxytryptamine precursors in normal man.

Six healthy male subjects received equimolar amounts of two 5-hydroxytryptamine (5-HT) precursors, 5-hydroxy-L-tryptophan (5-HTP) and gamma-L-glutamyl-5-hydroxy-L-tryptophan (glu-5-HTP), on two occasions in a randomised cross-over study. There were marked increases in urinary 5-HTP and 5-HT excretion after infusion of both compounds. Mean urinary excretion rate of 5-HT, which was < 0.7 nmol min...

The dietary supplement 5-hydroxytryptophan and urinary 5-hydroxyindole acetic acid.

5- Hydroxytryptamine

eral kinetic systems and compares their properties (after cautioning the reader of the possible pitfalls and of the assumptions which must be made) with various biological phenomena such as regulation, regeneration, determination , gene action, pleiotropism, etc. Few biologists have been as successful as Waddington in accomplishing a synthesis between embryology and genetics. In this volume, he...

Tryptophan and 5-hydroxytryptophan for depression.

BACKGROUND 5 Hydroxytryptophan (5-HTP) and tryptophan are so-called natural alternatives to traditional antidepressants, used to treat unipolar depression and dysthymia. OBJECTIVES To determine whether 5-HTP and tryptophan are more effective than placebo, and whether they are safe to use to treat depressive disorders in adults. SEARCH STRATEGY Trials were searched in computerized general (M...

Precancerous Loss of 5-Hydroxytryptophan Decarboxylase Activity

The purpose of this experimental work was to determine whether the precancerous loss of rat liver 5-hydroxytryptophan (5-HT) decarboxylase was associated with sequential atrophic alterations preceding hepatocarcinogenesis. To test whether such an association existed, three experimental conditions were employed in which hepato carcinogenesis was either markedly delayed or prevented. Under all th...